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Selinexor (KPT-330)

Selinexor (KPT-330)
Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.
Catalog No. T6106Cas No. 1393477-72-9
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Purity:100%
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Selinexor (KPT-330)

Purity: 99.85%
Catalog No. T6106Alias Selinexor, KPT-330Cas No. 1393477-72-9

Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.
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Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$74In Stock
25 mg$281In Stock
50 mg$422In Stock
100 mg$481In Stock
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Product Introduction

Bioactivity
Description
Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.
In vitro
METHODS: Six T-ALL cells, MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3 and DND-41, were treated with Selinexor (0-1000 µM) for 72 h. Cell growth inhibition was detected using Cell Titer Glo assay.
RESULTS: Selinexor treatment inhibited T-ALL cell growth with IC50 values of 34-203 nM. [1]
METHODS: Multiple myeloma cells MM1S were treated with Selinexor (100 nM) for 8 h. The expression levels of target proteins were detected by Western Blot.
RESULTS: Selinexor treatment resulted in the accumulation of p53, IκB, p21 and p27 in the nucleus of MM1S cells. [2]
In vivo
METHODS: To assay antitumor activity in vivo, Selinexor (20-25 mg/kg) was administered by gavage to NSG mice harboring the human T-ALL tumor MOLT-4 three times per week for thirty-six days.
RESULTS: Selinexor-treated mice exhibited significant inhibition of leukemia cell growth with significant survival benefit. [1]
METHODS: To assay anti-tumor activity in vivo, Selinexor (20 mg/kg) was administered by gavage three times per week for four weeks to an NSG mouse model of primary AML in patients.
RESULTS: Selinexor was cytotoxic to primary AML cells transplanted into mice. [3]
AliasSelinexor, KPT-330
Chemical Properties
Molecular Weight443.31
FormulaC17H11F6N7O
Cas No.1393477-72-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8.2 mg/mL (18.5 mM), Working solution is recommended to be prepared and used immediately.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 38 mg/mL (85.7 mM)
DMSO: 55 mg/mL (124.07 mM)
Solution Preparation Table
10% DMSO+40% PEG300+5% Tween 80+45% Saline/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.2558 mL11.2788 mL22.5576 mL112.7879 mL
5 mM0.4512 mL2.2558 mL4.5115 mL22.5576 mL
10 mM0.2256 mL1.1279 mL2.2558 mL11.2788 mL
Ethanol/DMSO
1mg5mg10mg50mg
20 mM0.1128 mL0.5639 mL1.1279 mL5.6394 mL
50 mM0.0451 mL0.2256 mL0.4512 mL2.2558 mL
DMSO
1mg5mg10mg50mg
100 mM0.0226 mL0.1128 mL0.2256 mL1.1279 mL

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